报告题目：Fine Tuning Between Neuronal Activity and Oxidative Stress in Brain:  A Study Based on Ultramicroelectrodes

　　　　CNRS Full Professor

2009年12月11日（星期五）上午9:00-10:15

中科院化学所礼堂

Christian Amatore, 57, was educated at Ecole Normale Supérieure (ENS), the leading French educational and research center. He was Director of the Chemistry Department of ENS, Professor of Chemistry, and is now Director of Research in CNRS, Full Member of the French Académie des Sciences and Fellow of the Royal Society of Chemistry. Up to recently he was appointed one of the twenty members of the High Council of Science and Technology which advised the French Governments on scientific matters.

His researches involve the development of advanced electrochemical methodologies for investigating extremely complex mechanisms of organic and organometallic chemistry under the very conditions used by synthetic chemists. Amatore’s activity in kinetics is best illustrated by the rationalization of electron transfer catalysis, electron transfer activation of molecules and more recently by a thorough series of works relative to the elucidation of the most important mechanistic aspects of catalysis by homogeneous palladium complexes, an extremely active area in today’s catalysis for carbon-carbon bond making in fine chemical industry. The well recognized contributions of Amatore’s group in this area have opened new views for rationalizing these important processes which have already led to the development of new synthetic strategies.

Amatore’s contributions gave electrochemistry new concepts and new tools which are essential in offering electrochemistry new entries in several mechanistic problems in organic, inorganic, and organometallic chemistries and more recently into the biology of living cells. In this respect, one should stress his pioneering work in collaboration with Mark Wightman for the development and promotion of ultramicroelectrodes. This led to the precise detection of extremely minute fluxes of essential messengers emitted by living cells during their interactions within tissues and integrated organisms. These researches involve vesicular release of neurotransmitters, oxidative stress cellular bursts, as well as the intimate cooperative coupling of these basic processes within the brain.

These works correspond to over 360 primary research publications cumulating more than 12,500 citations and a “h-indice” of 59 (ISI Web of Knowledge, 2009). Amatore received many important French and international prizes and distinctions among which the Silver Medal (CNRS), the Reilley Award (SEAC), the de Broglie Medal (Academia dei Lincei), the Bourke Medal (RSC), the Galvani Medal (SCI) and the Faraday Medal (RSC). He has been distinguished lecturer in many outstanding universities (Oxford, Durham, Cornell, Pittsburgh, Caltech, Padova, Modena, Roma La Sapienza, Japan JSPS, etc.) is Honorary Professor or Doctor Honoris Causa of several universities in Europe and Asia.

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